DWYANE WADE

PLAYS 1-ON-1 WITH 90-YEAR-OLD

... Makes Us All Cry

54 MINUTES AGO BY TMZ STAFF
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This is just about the cutest damn thing you're gonna see all week ... Dwyane Wade turning a 90-year-old into a kid again ... by making her birthday wish of a 1-on-1 game come true.

The adorableness started when lluminadada Magtoto -- aka "Grandma Nelly" -- took to YouTube and challenged Wade to a mano a mano roundball duel to take place on her 90th birthday.

Dwyane got wind of her offer and, in awesome guy fashion, made her wish come true at Heat practice recently, shooting around with her and even finishing a lob she threw with a nice reverse lay up.

BONUS -- Wade even takes a dig at Mario Chalmers ... it's pretty funny. 

Check out the video -- Magoto says she's wanted to meet Wade "all her life," (mathematically impossible) and watching her live her dream certainly made us all misty.